منابع مشابه
Clinical and Laboratory Findings of Cup-Like Nuclei in Blasts with FLT3 Mutation in Pediatric Acute Myeloid Leukemia: A Case Report
Biologically, Acute myeloid leukemia (AML) is highly heterogenous. AML with cup-like blast morphology variant has been reported to have important role in risk group stratification and treatment implications. In pediatric age group, this morphology and its clinical implication is rarely discussed. Although this morphology variant is not stated in World Health Organization (WHO) classification of...
متن کاملCup-like acute myeloid leukemia: new disease or artificial phenomenon?
We investigated cup-like nuclear morphology of acute myeloid leukemia blasts in 266 randomly selected patients and its association with hematologic findings, disease markers and outcome data. Cup-like acute myeloid leukemia was diagnosed in 55 patients (21%). It was associated with female sex, high white blood cell and blast cell counts, normal karyotype, and low CD34 and HLA-DR expression. Mut...
متن کاملBlasts with rosette-like multinucleation in acute myeloid leukemia with complex cytogenetic abnormalities.
A 28-year-old female presented with chills, sweats, and profound weakness. Laboratory findings revealed hypercalcemia, elevated lactate dehydrogenase, and pancytopenia. Bone marrow aspirate revealed 95% blasts with 2 distinct populations. A subset of blasts (20%) had typical morphology with smallto medium-sized nuclei, relatively regular nuclear outlines, and scant cytoplasm; however, the major...
متن کاملDe novo acute myeloid leukemia with monocytoid blasts and erythrophagocytosis
KEY CLINICAL MESSAGE Acute myeloid leukemia (AML) with t(8:16) is an infrequent acute leukemia subtype. It can occur de novo or more frequently therapy-related. The presence of blasts with monocytoid morphology and erythrophagocytosis suggest the presence of the t(8;16).
متن کاملDe novo acute myeloid leukemia with 20-29% blasts is less aggressive than acute myeloid leukemia with ≥30% blasts in older adults: a Bone Marrow Pathology Group study.
It is controversial whether acute myeloid leukemia (AML) patients with 20-29% bone marrow (BM) blasts, formerly referred to as refractory anemia with excess blasts in transformation (RAEBT), should be considered AML or myelodysplastic syndrome (MDS) for the purposes of treatment and prognostication. We retrospectively studied 571 de novo AML in patients aged >50 years, including 142 RAEBT and 4...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2015
ISSN: 0361-8609
DOI: 10.1002/ajh.23954